Resistance to Molecular Therapies for Hepatocellular Carcinoma
| By: | null |
| Publisher: | Springer Nature |
| Print ISBN: | 9783319561967 |
| eText ISBN: | 9783319561974 |
| Edition: | 0 |
| Copyright: | 2017 |
| Format: | Page Fidelity |
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This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies.