Genomics of Pattern Recognition Receptors
Applications in Oncology and Cardiovascular Diseases| By: | Anton G. Kutikhin; Arseniy E. Yuzhalin |
| Publisher: | Springer Nature |
| Print ISBN: | 9783034806879 |
| eText ISBN: | 9783034806886 |
| Edition: | 0 |
| Copyright: | 2013 |
| Format: | Reflowable |
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This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.