Annotating New Genes: From in Silico Screening to Experimental Validation
| By: | Uchida, S |
| Publisher: | Elsevier S & T |
| Print ISBN: | 9781907568688 |
| eText ISBN: | 9781908818126 |
| Edition: | 0 |
| Format: | Page Fidelity |
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In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented.
- Focuses not only on screening but also on biological validations
- Provides details of databases and software (web interface) products for biologists with minimal computation skills
- Offers a step-by-step outline of the procedure involved