Control of Animal Cell Proliferation

Control of Animal Cell Proliferation, Volume I presents how animals regulate their proliferation activity and how cells become proliferatively autonomous resulting in malignant behavior. This book provides an understanding of mechanisms that control animal cell proliferation. Organized into five parts encompassing 17 chapters, this volume begins with an overview of the efforts to elucidate he genetic alterations that lead normal cells to become cancer cells, which have been aided considerably by the investigation of acute retroviruses. This text then examines the factors involved in growth control. Other chapters describe in detail the biology and biochemistry of epidermal growth factor (EGF), which have been elucidated through the study of cultured human fibroblasts. This book discusses as well the protein kinases with specificity for tyrosine. The final chapter deals with regulation of initiation of eukaryotic protein synthesis by phosphorylation. This book is a valuable resource for scientists as well as cellular and molecular biologists.