Lysosomes
Biology, Diseases, and Therapeutics| By: | Frederick R. Maxfield; James M. Willard; Shuyan Lu |
| Publisher: | Wiley Global Research (STMS) |
| Print ISBN: | 9781118645154 |
| eText ISBN: | 9781118978313 |
| Edition: | 1 |
| Copyright: | 2016 |
| Format: | Reflowable |
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Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development