Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
| By: | Ayman F. El-Kattan; Mike S. Lee |
| Publisher: | Wiley Global Research (STMS) |
| Print ISBN: | 9781118916698 |
| eText ISBN: | 9781118916933 |
| Edition: | 1 |
| Copyright: | 2017 |
| Format: | Reflowable |
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability - one of the most significant hurdles in drug discovery and development.
• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
• Explains how preclinical animal models - used in preclinical testing - and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development