Influenza Viruses

Influenza virus infections are a serious health problem. Each year, about 500 million people are infected by the virus, resulting in about 500,000 deaths worldwide. The occurrence of new influenza subtypes has caused severe pandemics, including the 2009 swine flu (vH1N1). In addition, highly pathogenic viruses, like subtypes H7N7 and H5N1, also called the fowl plague and bird flu, respectively, represent enormous economic threats to livestock farming. This book begins with descriptions of the molecular make-up of influenza viruses, their replication cycles and functions of viral proteins. A history of major influenza pandemics is provided as is a detailed article discussing how viral growth and decay is mathematically modeled to evaluate the biological parameters governing interaction between host and virus. Several laboratory protocols describe how influenza virus is handled and used in animal models to study host-pathogen interactions and test potential new therapies. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of influenza research for students or interdisciplinary collaborators. Table of Contents: Introduction Influenza Viruses: Molecular Virology eLS Gabriele Neumann and Yoshihiro Kawaoka Avian Influenza Viruses eLS Gabriele Neumann and Yoshihiro Kawaoka Influenza Epidemics and Pandemics eLS Gabriele Neumann and Yoshihiro Kawaoka Parainfluenza Viruses eLS Raychel Chambers and Toru Takimoto Disease Modeling Influenza A Virus Infection Kinetics: Quantitative Data and Models WIREs Systems Biology and Medicine Amber M. Smith and Alan S. Perelson Protocols Laboratory Growth and Maintenance of Haemophilus influenzae Current Protocols in Microbiology Jason W. Johnston Influenza: Propagation, Quantification and Storage Current Protocols in Microbiology Amanda L. Balish, Jacqueline M. Katz and Alexander I. Klimov The Mouse as Model System to Study Host?]Pathogen Interactions in Influenza A Infections Current Protocols in Mouse Biology Esther Wilk and Klaus Schughart